Disease	Causative Agent	Classic Clinical Presentation	Incubation Period	Laboratory Testing	Treatment
Babesiosis	Babesia microti (protozoan)	Fever Hemolytic anemia Constitutional symptoms	1-52 weeks	Trophozoites or merozoites in peripheral blood smear. Compatible clinical symptoms IFA Serology	Clindamycin/ Quinine**
Human GranulocyticEhrlichiosis	Ehrlichia sp. (bacterium)	Fever Headache Constitutional symptoms	7-21 days	Morulae in cytoplasm of leukocytes. Compatible clinical symptoms and laboratory findings. IFA, PCR.	Adults -tetracyclines*** Children and pregnant women-consult ** specialist.
Human Monocytic Ehrlichiosis	Ehrlichia chaffeenesis (bacterium)	Fever Headache Constitutional symptoms	7-21 days	Morulae in cytoplasm of leukocytes. Compatible clinical symptoms and laboratory findings. IFA, PCR.	Adults -tetracyclines*** Children and pregnant women-consult ** specialist.
Lyme Disease	Borrelia burgdorferi (bacterium)	EM rash Constitutional symptoms Arthritis Cardiovascular and nervous system involvement	3-30 days	Compatible clinical symptoms EIA or IFA screen with Western Blot confirmation. Positive culture.	Variety of antibiotics **
Rocky Mountain Spotted Fever	Rickettsia rickettsii (bacterium)	Sudden mod-high fever Severe headache Maculopapular rash (with planter/palmer presentation)	2-14 days	Compatible clinical symptoms IFA, DFA (skin or organ tissue.)	Adults -tetracyclines**** Children and pregnant women -consult ** specialist.

*Annals of Internal Medicine, May 1994, 120 (9):736-43
**1994 Red Book, Report of the Committee on Infectious Disease, American Academy of Pediatrics
***Ehrlichia Diseases of Humans: Emerging Tick-Borne Infections Clinical Infectious Diseases, 1995, 20:1102-1110
****Mandell/Douglas/Bennett: Principles and Practices of Infectious Disease